Monotherapy Initially 100 mg bid, increased to 150 mg bid after 1 wk. May be further increased at wkly interval by 50 mg bid (100 mg daily) depending on response & tolerability. Max maintenance dose: 200 mg bid (400 mg daily).
Conversion to monotherapy Initially 100 mg bid, increased to 150 mg bid after 1 wk. May be further increased at wkly interval by 50 mg bid (100 mg daily). Max maintenance dose: 200 mg bid (400 mg daily).
Adjunctive therapy Initially 50 mg bid, increased to initial therapeutic dose of 100 mg bid after 1 wk. May be further increased by 50 mg bid (100 mg daily) every wk. Max maintenance dose: 200 mg bid (400 mg daily).
Initiation w/ loading dose Initiate w/ single loading dose of 200 mg, followed approx 12 hr later by 100 mg bid (200 mg daily) maintenance dose. Can be further increased by 50 mg bid wkly. Max maintenance dose: 200 mg bid (400 mg daily).
Severe renal impairment (CrCl ≤30 mL/min) & ESRD, mild to moderate hepatic impairment Max: 300 mg daily.
Patient requiring haemodialysis Supplement of up to 50% of divided daily dose directly after end of haemodialysis.
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